教員プロフィール

伊田　喜光

伊田　喜光
Ida Yoshiteru

漢方薬学科　天然物化学研究室 (教授)
/ 学生部長　[昭和大学 名誉教授・客員教授]
 

◆最終学歴
九州大学大学院 薬学研究科 博士課程中退 (生薬学･植物化学専攻)

 

◆取得学位
薬学博士 (九州大学)

 

◆所属学会
日本薬学会, 日本生薬学会, 日本化学会, 東洋医学会, 和漢医薬学会, 日本癌学会, 日本食糧学会

 

◆現在の専門分野
生薬学・天然物化学

 

◆現在の研究課題
生薬および薬用植物の成分研究；有用天然物質の開発研究；漢方薬の有効性に関する科学的研究

 

◆最近の主要研究内容と業績
最近５年余りの主な研究内容は次の通りです。
(いずれも，元の職場である昭和大学 薬学部 生薬学･植物薬品化学教室との共同研究)

  1.  ゴシツとキキョウから，それぞれ十数種のトリテルペノイド配糖体を単離・構造決定しました。現在，これらのサポニンについてガン細胞増殖抑制活性に関する研究を進めています
  2.  サポニンの細胞毒性に関する研究：ステロイドやトリテルペンの配糖体であるサポニンの多くは界面活性作用をもち，溶血作用を示すことが知られています。数年前，共同研究者の口野嘉幸教授 (本学漢方治療学研究室/元国立癌センター研究所生物物理部長) が，私たちが植物より単離した数種サポニンに強いガン細胞増殖抑制活性があることを見出しました。この研究が，現在，そのガン細胞増殖抑制活性発現メカニズムに関する研究に発展しています。
  3.  アズキは古くから浮腫の治療にも用いられてきました。この活性本体を明らかにすべく研究を行っています。現在までに十数種のフラボノイド誘導体 (ポリフェノールの類) を単離・同定し，これらがいずれも強いラジカル消去能をもつことを明らかにしました。現在，これらの生理活性について研究を続けています。
  4.  ショウキョウとカンキョウは，共にショウガの根茎からつくられる生薬です。漢方ではこの二つの使用目的が違います。これらに関する研究の結果，薬効の違いは両者の成分に若干の違いによることがわかりました。この研究の副産物として，現在の市場品は，調製法が昔の方法から変わったために，成分の一部がスルホン化されることが明らかになりました。現在，この成分変化が薬効にもたらす影響について研究を続けています。
  5.  健胃薬として有名なゲンチアナは，元々ヨーロッパ原産の薬用植物で，今なお多くの胃腸薬に配合されています。これらは全てヨーロッパからの輸入品が使われていますが，北海道ではここ数十年にわたってゲンチアナの試験栽培が続けられてきました。これが生薬資源として有用であるか否かを検討するために成分研究を行っています。
 

◆論　文 (2001年～)

Dihydrochalcone designed from methylophiopogonanone B strongly inhibits hypoxia-inducible factor (HIF)-1 activity: Fujii, Mikio; Egawa, Kiyoshi; Hirai, Yasuaki; Kondo, Masato; Fujii, Kotaro; Uekusa, Hidehiro; Akita, Hiroyuki; Nose, Kiyoshi; Toriizuka, Kazuo; Ida, Yoshiteru, Heterocycles (2009), 78 (8), 2061-2065

Achyranthoside H methyl ester, a novel oleanolic acid saponin derivative from Achyranthes fauriei roots, induces apoptosis in human breast cancer MCF-7 and MDA-MB-453 cells via a caspase activation pathway: Fukumura M, Ando H, Hirai Y, Toriizuka K, Ida Y, Kuchino Y., Journal of Natural Medicines (Tokyo) (2009), 63 (2), 181-188.

Constituents and Antioxidative Activity of the Hot-Water Extract of Adzuki (Vigna angularis) Beans: Hori Y, Murakoso T, Fukumura M, Toriizuka K, Ida Y., J. Jpn. Soc. Nutr. Food Sci. (2009), 62 (1), 1-10.

First synthesis of racemic methylophiopogonanone B and its inhibitory activity of hypoxia-inducible factor-1〈: Fujii M, Egawa K, Hirai Y, Kondo M, Akita H, Nose K, Toriizuka K, and Ida Y., Heterocycles (2009), 78 (1), 207-212.

Preparation of methylendioxyanphetamine antibody and the reactivity of the related compounds: Tanaka S, Watanabe S, Furuya K, Nomura T, Kaizaki A, Ito K, Fujii M, Hori Y, Actor N, Aoki K, Numazawa S, Toriizuka K, Arakawa H, Ida Y and Yoshida T., Japanese Journal of Forensic Science and Technology (2008), 13 (2) 125-132.

Two new glucuronide saponins, Achyranthosides G and H, from Achyranthes fauriei root: Ando H, Fukumura M, Hori Y, Hirai Y, Toriizuka K, Kuchino Y, Ida Y, Journal of Natural Medicines (2008), 62 (1), 57-62.

Control of chemoselectivity of microbial reaction with resin adsorbent: enhancement of Baeyer-Villiger oxidation over reduction: Fujii M., Akita H., Ida Y., Nakagawa T. and Nakamura K., Appl. Microbiol. Biotechnol. (2007) 77 (1), 45-51.

Synthesis of both enantiomers of 1-phenylethanol by reduction of acetophenenone with Geotrichum candidum IFO 5767: Nakamura K, Fujii M, Ida Y., Catalysts for Fine Chemical Synthesis (2007), 5, 93-97. (John Wiley & Sons Ltd.)

Control of chemoselectivity of microbial reaction with resin adsorbent: enhancement of Baeyer-Villiger oxidation over reduction: Fujii, Mikio; Akita, Hiroyuki; Ida, Yoshiteru; Nakagawa, Toshiya; Nakamura, Kaoru, Applied Microbiology and Biotechnology (2007), 77 (1), 45-51.

The chemical constituents of fresh Gentian root: Ando, Hidehiro; Hirai, Yasuaki; Fujii, Mikio; Hori, Yumiko; Fukumura, Motonori; Niiho, Yujiro; Nakajima, Yoshijiro; Shibata, Toshiro; Toriizuka, Kazuo; Ida, Yoshiteru., Journal of Natural Medicines (2007), 61 (3), 269-279.

Synthesis and characterization of novel N-para-ferrocenyl benzoyl dipeptide esters: Savage, David; Alley, Steven R.; Goel, Alok; Hogan, Tara; Ida, Yoshiteru; Kelly, Paula N.; Lehmann, Laurent; Kenny, Peter T. M., Inorganic Chemistry Communications (2006), 9 (12), 1267-1270.

Chemoenzymatic synthesis of optically active γ -alkyl-γ -butenolides: Fujii, Mikio; Fukumura, Motonori; Hori, Yumiko; Hirai, Yasuaki; Akita, Hiroyuki; Nakamura, Kaoru; Toriizuka, Kazuo; Ida, Yoshiteru, Tetrahedron: Asymmetry (2006), 17 (15), 2292-2298.

First synthesis of polyoxin M: Shiro, Yuuichi; Kato, Keisuke; Fujii, Mikio; Ida, Yoshiteru; Akita, Hiroyuki., Tetrahedron (2006), 62 (37), 8687-8695.

Chemoenzymatic synthesis of naturally occurring geranyl 6-O-glycosyl β-D-glucopyranosides: Kawahara, Eiji; Fujii, Mikio; Ida, Yoshiteru; Akita, Hiroyuki, Heterocycles (2006), 68 (2), 323-330.

Chemo-enzymatic synthesis of sacranosides A and B. : Kawahara, Eiji; Fujii, Mikio; Ida, Yoshiteru; Akita, Hiroyuki, Chemical & Pharmaceutical Bulletin (2006), 54 (3), 387-390.

Gastroprotective effects of bitter principles isolated from Gentian root and Swertia herb on experimentally-induced gastric lesions in rats: Niiho, Yujiro; Yamazaki, Takashi; Nakajima, Yoshijiro; Yamamoto, Toshinori; Ando, Hidehiro; Hirai, Yasuaki; Toriizuka, Kazuo; Ida, Yoshiteru, Journal of Natural Medicines (2006), 60 (1), 82-88.

Lupane-Type Saponins from Leaves of Acanthopanax sessiliflorus and Their Inhibitory Activity on Pancreatic Lipase: Yoshizumi, Kazuma; Hirano, Kaoru; Ando, Hidehiro; Hirai, Yasuaki; Ida, Yoshiteru; Tsuji, Tomoko; Tanaka, Tamotsu; Satouchi, Kiyoshi; Terao, Junji, Journal of Agricultural and Food Chemistry (2006), 54 (2), 335-341.

Sulfonated compounds in Shokyo and Kankyo: Hori, Yumiko; Wakabayashi, Yukiye; Oheda, Minoru; Mizui, Kayoko; Fukumura, Motonori; Hirai, Yasuaki; Nemoto, Yukio; Toriizuka, Kazuo; Ida, Yoshiteru, Journal of Natural Medicines (Tokyo, Japan) (2005), 59 (5), 229-236.

Five monoterpene glycosides from Zingiberis rhizome (Shokyo): Hori, Yumiko; Miura, Tsuyoshi; Wakabayashi, Yukiye; Fukumura, Motonori; Hirai, Yasuaki; Toriizuka, Kazuo; Kuchino, Yoshiyuki; Ida, Yoshiteru, Heterocycles (2005), 65 (10), 2357-2367.

Chemoenzymatic synthesis of naturally occurring benzyl 6-O-glycosyl-β-D-glucopyranosides: Kawahara, Eiji; Fujii, Mikio; Kato, Keisuke; Ida, Yoshiteru; Akita, Hiroyuki, Chemical & Pharmaceutical Bulletin (2005), 53 (8), 1058-1061.

Chemoenzymatic synthesis of naturally occurring (Z)-3-hexenyl 6-O-glycosyl-β-D-glucopyranosides: Kishida, Masashi; Fujii, Mikio; Ida, Yoshiteru; Akita, Hiroyuki, Heterocycles (2005), 65 (9), 2127-2137.

Chemo-enzymic synthesis of naturally occurring phenethyl(1→ 6)-β-D-glucopyranosides: Kawahara, Eiji; Nishiuchi, Miho; Fujii, Mikio; Kato, Keisuke; Ida, Yoshiteru; Akita, Hiroyuki, Heterocycles (2005), 65 (6), 1461-1470.

The case for a shift in pharmacists' activities and pharmacy education - Based on those in the English speaking western countries: Watanabe, Tomoko; Ohtani, Yusaku; Yamamoto, Toshinori; Nemoto, Yukio; Ida, Yoshiteru; Bachynsky, John Alexander, Yakugaku Zasshi (2005), 125 (3), 283-292.

Pharmaceutical terms reflecting the change in practice in Japan: Watanabe, Tomoko; Ohtani, Yusaku; Yamamoto, Toshinori; Nemoto, Yukio; Ida, Yoshiteru; Bachynsky, John Alexander, Yakugaku Zasshi (2005), 125 (3), 271-281.

Synthesis and structural characterization of N-para-ferrocenyl benzoyl amino acid ethyl esters and the X-ray crystal structures of the glycyl and (± )-2-aminobutyric acid derivative Fc-C6H4CONHCH(C2H5)CO2Et: Savage, David; Malone, Gwen; Gallagher, John F.; Ida, Yoshiteru; Kenny, Peter T. M., Journal of Organometallic Chemistry (2005), 690 (2), 383-393.

Synthesis and structural characterization of redox-responsive N-ferrocenoyl amino acid esters; the X-ray crystal structure of N-ferrocenoyl alanine methyl ester; electrochemical anion recognition and 1H NMR complexation studies: Sheehy, Michael J.; Gallagher, John F.; Yamashita, Mashita; Ida, Yoshiteru; White-Colangelo, Jennifer; Johnson, Jeremi; Orlando, Ron; Kenny, Peter T. M., Journal of Organometallic Chemistry (2004), 689 (9), 1511-1520.

Simple synthesis of β -D-glycopyranosides using β -glycosidase from almonds: Kurashima, Katsumi; Fujii, Mikio; Ida, Yoshiteru; Akita, Hiroyuki, Chemical & Pharmaceutical Bulletin (2004), 52 (2), 270-275.

Specific inhibition of hypoxia-inducible factor (HIF)-1α activation and of vascular endothelial growth factor (VEGF) production by flavonoids: Hasebe, Yuki; Egawa, Kiyoshi; Yamazaki, Yoko; Kunimoto, Setsuko; Hirai, Yasuaki; Ida, Yoshiteru; Nose, Kiyoshi, Biological & Pharmaceutical Bulletin (2003), 26 (10), 1379-1383.

Enzymatic β -glycosidation of primary alcohols: Kurashima, Katsumi; Fujii, Mikio; Ida, Yoshiteru; Akita, Hiroyuki, Journal of Molecular Catalysis B: Enzymatic (2003), 26 (1-2), 87-98.

Glycosides of Atractylodes ovata: Kitajima, Junichi; Kamoshita, Akane; Ishikawa, Toru; Takano, Akihito; Fukuda, Tatsuo; Isoda, Susumu; Ida, Yoshiteru, Chemical & Pharmaceutical Bulletin (2003), 51 (9), 1106-1108.

Aggregation of RecA-derived peptides on single-stranded oligonucleotides triggered by Schiff base-mediated crosslinking: Sugiyama, Toru; Kittaka, Atsushi; Takayama, Hiroaki; Tomioka, Mitsugu; Ida, Yoshiteru; Kuroda, Reiko, Bioorganic & Medicinal Chemistry Letters (2003), 13 (17), 2847-2851.

Glycosides of Atractylodes lancea: Kitajima, Junichi; Kamoshita, Akane; Ishikawa, Toru; Takano, Akihito; Fukuda, Tatsuo; Isoda, Susumu; Ida, Yoshiteru, Chemical & Pharmaceutical Bulletin (2003), 51 (6), 673-678.

Glycosides of Atractylodes japonica: Kitajima, Junichi; Kamoshita, Akane; Ishikawa, Toru; Takano, Akihito; Fukuda, Tatsuo; Isoda, Susumu; Ida, Yoshiteru, Chemical & Pharmaceutical Bulletin (2003), 51 (2), 152-157.

Pharmacognostic studies on ginger and related drugs-part 1: Five sulfonated compounds from Zingiberis rhizome (Shokyo). : Hori, Yumiko; Miura, Tsuyoshi; Hirai, Yasuaki; Fukumura, Motonori; Nemoto, Yukio; Toriizuka, Kazuo; Ida, Yoshiteru, Phytochemistry (2003), 62 (4), 613-617.

Effect of nutritive and tonic crude drugs on physical fatigue-induced stress models in mice: Tadano Takeshi; Nakagawasai Osamu; Niijima Fukie; Tan-no Koichi; Hanawa Masa-aki; Sakata Yasuko; Sutoo Den'etsu; Nemoto Yukio; Ida Yoshiteru; Endo Yasuo, Pharmacological Research (2003), 47 (3), 195-9.

Semi-rigid N-p-ferrocenyl(benzoyl)amino-acid esters for biomaterials: synthesis and characterization of Fc-C6H4CONHCH(R)CO2Me where Fc = (η-C5H5)Fe(η5-C5H4) and R = H, CH3, CH2CH(CH3)2, CH2C6H5, and the X-ray crystal structures of Fc-C6H4CO2Me and the l-alanine derivative Fc-C6H4CONHCH(CH3)CO2Me: Savage D., Gallagher J. F., Ida Y. and Kenny P. T. M., Inorganic Chemistry Communications, 5 (12), 1034-1040 (2002).

Five triterpene glycosides from Oxytropis myriophylla: Okawa M., Yamaguchi R., Delger H., Tsuchihashi R., Nohara T., Kinjo J., Isoda S. and Ida Y., Chem. Pharm. Bull., 50 (8), 1097-1099 (2002).

Sophoranone, extracted from a traditional Chinese medicine Shan Dou Gen, induces apoptosis in human leukemia U937 cells via formation of reactive oxygen species and opening of mitochondrial permeability transition pores: Kajimoto S., Takanashi N., Kajimoto T., Xu M., Cao J., Masuda Y., Aiuchi T., Nakajo S., Ida Y. and Nakaya K., International Journal of Cancer, 99 (6), 879-890 (2002).

Asymmetric synthesis of both enantiomers of secondary alcohols by reduction with a single microbe: Nakamura K., Takenaka K., Fujii M. and Ida Y., Tetrahedron Letters, 43 (20), 3629-3631 (2002).

Stereoinversion of arylethanols by Geotrichum candidum: Nakamura K., Fujii M. and Ida Y., Tetrahedron: Asymmetry, 12 (22), 3147-3153 (2001).

Chemical cross-linking of peptides derived from RecA with single-stranded oligonucleotides containing 5-formyl-2'-deoxyuridine: Sugiyama T., Kittaka A., Takayama H., Tomioka M., Ida Y. and Kuroda R., Nucleosides, Nucleotides & Nucleic Acids, 20 (4-7), 1079-1083 (2001).