横浜薬科大学 薬学部

最終学歴

東北薬科大学大学院　薬学研究科　修士課程修了（有機薬化学専攻）

取得学位

薬学博士（東北薬科大学）

所属学会

日本薬学会，日本生薬学会，東洋医学会

現在の専門分野

天然物化学

現在の研究課題

漢方薬主要成分の生体内代謝物の構造決定および薬理作用

主要研究業績

釣藤散の構成生薬である釣藤鉤に含まれる2種のインドールアルカロイドをラットに経口投与し，その生体内代謝物について検討した。その結果、各々2種計4種の代謝物を単離し，構造を決定した。ひき続きそれらの薬理作用を検討している。

最近の研究業績

1. Metabolites of Hirsuteine and,Hirstine,the major indole alkaloids of Uncaria rhynchoph-ylla,in rats:Takahiro,Nakazawa;Ko-ichi,Banba;Kazumasa,Hata;Yutaka,Nihei;Ayumi,Hoshik-awa;Keisuke,Ohsawa,Biological&Pharmaceutical Bulletin(2006),29(8),1671-1677.
2. Metabolic fate of Fraxin administered orally to rats:Takaaki,Yasuda;Mai,Fukui;Takahiro,Nakazawa;Ayumi,Hoshikawa;Keisuke,Ohsawa,Fournal of Natural Products(2006),69(5), 755-757.
3. Antipyretic,analgesic and muscle relaxant activities of Pueraria isoflavonoids and their metabolites from Pueraria lobata Ohwi-a traditional chinese drug:Takaaki,Yasuda;Miwa,Endo;Toshiyuki,Kon-no;Tomoko,Kato;Mariko,Mitsuzuka;Keisuke,Ohsawa,Chemical&Pharm-aceutical Bulletin(2005),28(7),1224-1228.
4. Metabolic fate of orally administered Phyllodulcin in rats:Takaaki,Yasuda;Saiko,Kayaba;Kana,Takahashi;Takahiro,Nakazawa;Keisuke,Ohsawa,Journal of Natural Products(2004), 67(9),1604-1607.
5. Effect of Kampo medicines on the peripheral blood flow rats of betamethason-induced Oketu syndrome mice by Laser doppler flow meter:Joji,Ueda;Etsuko,Ohya;Kozue,Udaga-wa;Akiko,Hara;Mai,Fukui;Hirokazu,Yamagishi;Takahiro,Nakazawa;Takaaki,Yasuda; Keisuke,Ohsawa,Yakugaku Zasshi(2004),124(6),365-369.
6. Urinary metabolites of Nobiletin orally administered to rats;Takaaki,Yasuda;Yukako,Yos-himura;Hisako,Yabuki;Takahiro,Nakazawa;Keisuke,Ohsawa,Chemical&Pharmaceutical Bulletin(2003),51(12),1426-1428.
7. Antidepressant-like effects of Magnolia officinalis in the forced swimming test:Takahiro,Nakazawa;Takaaki,Yasuda; Keisuke Ohsawa,Natural Medicines,57(6),221-226(2003).
8. Metabolites of orally administered Magnolia officinalis extract in rats and man and antidipressant-like effects in mice:Takahiro,Nakazawa;Takaaki,Yasuda;Keisuke Ohsawa,Journal of Pharmacy and Pharmacology(2003),55(11),1583-1591.
9. Antidepressant-like effects of Apigenin and 2,4,5-Trimethoxycinnamic acid from Perilla frutescens in the forced swimming test:Takahiro,Nakazawa;Takaaki,Yasuda;Joji,Ueda,Keisuke Ohsawa,Biological&Pharmaceutical Bulletin(2003),26(4),474-480.
10. Inhibitory effects of urinary metabolites on platelet aggregation after orally administer-ring Shimotsu-To,a traditional chinese medicine,to rats;Takaaki,Yasuda;Akie,Takasawa;Takahiro,Nakazawa;Joji,Ueda;Keisuke,Ohsawa,Journal of Pharmacy and Pharmacology(2003),55(2),258-260.
11. Determination of trans-ferulic acid in Shimotsu-To,a traditional chinese medicine,by high-performance liguid chromatography:Takaaki,Yasuda;Akie,Takazawa;Takahiro,Nakaza-wa;Joji,Ueda;Keisuke,Ohsawa,Natural Medicines(2002),56(6),258-260.
12. Metabolism of [6]-gingerol in rats:Takahiro,Nakazawa;Keisuke,Ohsawa,LifeSciences(2002),70,2165-2175.
13. Urinary metabolites of Genistein administered orally to rats:Takaaki,Yasuda;Joji,Ueda;Keisuke,Ohsawa,Chemical&Pharmaceutical Bulletin(2001),49(11),1495-1497.