教員プロフィール

細谷 孝博

細谷 孝博

細谷 孝博

Hosoya Takahiro

漢方薬学科/薬品分析学研究室(講師)

最終学歴

千葉大学大学院医学薬学府創薬生命科学専攻 博士課程修了

取得学位

博士(薬学)

所属学会

日本薬学会、日本生薬学会

現在の専門分野

分析化学、天然物化学

現在の研究課題
  • 天然からの生理活性化合物の単離・構造決定
主要研究業績
  • 生理活性を有する天然物の単離・構造決定
  • 生理活性天然物の作用機序の解明
  • NMRやMSを用いた天然物の網羅的解析技術の開発
最近の研究業績
  1. Koharu Okumura, Takahiro Hosoya, Kai Kawarasaki, Norihiko Izawa, Shigenori Kumazawa: Antioxidant activity of phenolic compounds from fava bean sprouts J. Food Sci. 2016, 81, 1394−1398.
  2. Shuhei Yoshida, Takahiro Hosoya, Saori Inui, Hideki Masuda, Shigenori Kumazawa. Component analysis of wasabi leaves and an evaluation of their anti-inflammatory activity. Food Sci. Technol. Res. 2015, 21, 247−253.
  3. Chiemi Moriya, Takahiro Hosoya, Sayuri Agawa, Yasumasa Sugiyama, Ikuko Kozone, Kazuo Shin-ya, Norihiko Terahara, Shigenori Kumazawa. New acylated anthocyanins from purple yam and their antioxidant activity. Biosci. Biotechnol. Biochem. 2015, 79, 1484−1492.
  4. Hong-Sook Bae, Hyun Ju Kim, Jin Hee Kang, Rika Kudo, Takahiro Hosoya, Shigenori Kumazawa, Mira Jun, Oh-Yoen Kim, Mok-Ryeon Ahn. Anthocyanin profile and antioxidant activity of various berries cultivated in Korea. Nat. Prod. Commun. 2015, 10, 963−968.
  5. Koichi Fujiwara, Hirokazu Tsukamoto, Miho Izumikawa, Takahiro Hosoya, Noritaka Kagaya, Motoki Takagi, Hideki Yamamura, Masayuki Hayakawa, Kazuo Shin-ya, Takayuki Doi. Total synthesis and structure determination of JBIR-108-A 2-hydroxy-2-(1-hydroxyethyl)-2,3- dihydro-3(2H)-furanone isolated from Streptomyces gramineus IR087Pi-4. J. Org. Chem. 2015, 80, 114−132.
  6. Michiko Torii Yasuda, Kotone Fujita, Takahiro Hosoya, Shinjiro Imai, Kayoko Shimoi. Absorption and metabolism of luteolin and its glycosides from the extract of Chrysanthemum morifolium flowers in rats and Caco-2 cells. J. Agric. Food Chem. 2015, 63, 7693−7699.
  7. Masato Nishizawa, Takahiro Hosoya, Takatsugu Hirokawa, Kazuo Shin-ya, Shigenori Kumazawa. NMR spectroscopic characterization of inclusion complexes of theaflavin digallate and cyclodextrins. Food Sci. Technol. Res. 2014, 20, 663−669.
  8. Michiyo Kubota, Takahiro Hosoya, Syuichi Fukumoto, Tsuyoshi Miyagi, Shigenori Kumazawa. Anti-melanogenic compounds in Rubus croceacanthus. J. Berry Res. 2014, 4, 127−135.
  9. Jun Deguchi, Kaori Horiguchi, Chin Piow Wong, Takahiro Hosoya, Akane Iihoshi, Toshio Kaneda, Hiroshi Morita. Sucutinirane-deterpene derivatives induce apoptosis via oxidative stress in HL-60 cells. J. Nat. Med. 2014, 68, 723−729.
  10. Makoto Kobayashi, Masato Nishizawa, Nao Inoue, Takahiro Hosoya, Masahito Yoshida, Yuichi Ukawa, Yuko M Sagesaka, Takayuki Doi, Tsutomu Nakayama, Shigenori Kumazawa, Ikuo Ikeda. Epigallocatechin gallate decreases the micellar solubility of cholesterol via specific interaction with phosphatidylcholine. J. Agric. Food Chem. 2014, 62, 2881−2890.
  11. Saori Inui, Ai Hatano, Megumi Yoshino, Takahiro Hosoya, Yuko Shimamura, Shuichi Masuda, Mok-Ryeon Ahn, Shigemi Tazawa, Yoko Araki, Shigenori Kumazawa. Identification of the phenolic compounds contributing to antibacterial activity in ethanol extracts of Brazilian red propolis. Nat. Prod. Res. 2014, 28, 1293−1296.
  12. Saori Inui, Takahiro Hosoya, Shigenori Kumazawa. Hawaiian propolis: comparative analysis and botanical origin. Nat. Prod. Commun. 2014, 9, 165−166.
  13. Takahiro Hosoya, Motoki Takagi, Kazuo Shin-ya. Pyridone alkaloids JBIR-130, JBIR-131, and JBIR-132 from Isaria sp. NBRC104353. J. Antibiot. 2013, 66, 235−238.
  14. Ikumi Tsuchiya, Takahiro Hosoya, Motoko Uchida, Kazuhiro Kunimasa, Toshiro Ohta, Shigenori Kumazawa. Nymphaeol-A isolated from Okinawan propolis suppresses angiogenesis and induces caspase-dependent apoptosis via inactivation of survival signals. Evid. Based Comp. Altern. Med. 2013, Article ID 826245.
  15. Jun Deguchi, Yusuke Motegi, Asami Nakata, Takahiro Hosoya, Hiroshi Morita. Cyclic diarylheptanoids as inhibitors of NO production from Acer nikoense. J. Nat. Med. 2013, 67, 234−239.
  16. Kazumasa Zaima, Ikumi Koga, Nobuhide Iwasawa, Takahiro Hosoya, Yusuke Hirasawa, Toshio Kaneda, Intan Safinar Ismail, Nordin Hj Lajis, Hiroshi Morita. Vasorelaxant activity of indole alkaloids from Tabernaemontana dichotoma. J. Nat. Med. 2013, 67, 9−16.
  17. Yuta Nagakura, Alfarius E. Nugroho, Yusuke Hirasawa, Takahiro Hosoya, Abdul Rahman, Idha Kusumawati, Noor Cholies Zaini, Hiroshi Morita. Sanjecumins A and B: new limonoids from Sandoricum koetjape. J. Nat. Med. 2013, 67, 381−385.
  18. Takahiro Hosoya, Asami Nakata, Fumie Yamasaki, Faridah Abas, Khozirah Shaari, Nordin Hj Lajis, Hiroshi Morita. Curcumin-like diarylpentanoid analogues as melanogenesis inhibitors. J. Nat. Med. 2012, 66, 166−176.
  19. Takahiro Hosoya, Takatsugu Hirokawa, Motoki Takagi, Kazuo Shin-ya. Trichostatin analogues JBIR-109, JBIR-110, and JBIR-111 obtained from a marine sponge-derived Streptomyces sp. RM72. J. Nat. Prod. 2012, 75, 285−289.
  20. Masahiko Imai, Bo Yuan, Hidetomo Kikuchi, Mai Saito, Kunio Ohyama, Chieko Hirobe, Takashi Oshima, Takahiro Hosoya, Hiroshi Morita, Hiroo Toyoda. Growth inhibition of a human colon carcinoma cell, COLO 201, by a natural product, Vitex agnus-castus fruits extract, in vivo and in vitro. Adv. Biol. Chem. 2012, 2, 20−28.
  21. Miho Izumikawa, Takahiro Hosoya, Motoki Takagi, Kazuo Shin-ya. A new cyclizidine analog -JBIR102- from Saccharopolyspora sp. RL78 isolated from mangrove soild. J. Antibiot. 2012, 65, 41−43.
  22. Naoko Kuzumaki, Atsuo Suzuki, Michiko Narita, Takahiro Hosoya, Atsumi Nagasawa, Satoshi Imai, Kohei Yamamizu, Hiroshi Morita, Tsutomu Suzuki, Yohei Okada, Hirotaka James Okano, Jun K. Yamashita, Hideyuki Okano, Minoru Narita. Multiple analyses of G-protein coupled receptor (GPCR) expression in the developmentof gefitinib-resistance in transforming non-small-cell lung cancer. PLoS One 2012, 7, e44368.
  23. Noriko Kuzumaki, Atsuo Suzuki, Michiko Narita, Takahiro Hosoya, Asami Nagasawa, Satoshi Imai, Kohei Yamamizu Hiroshi Morita, H. Nagase, Yohei Okada, Hirotaka James Okano, Jun K. Yamashita, Hideyuki Okano, Tutomu Suzuki, Minoru Narita. Effect of κ-opioid receptor agonist on the growth of non-small cell lung cancer (NSCLC) cells. Br. J. Cancer 2012, 106, 1148−1152.
  24. Saori Inui, Takahiro Hosoya, Yuko Shimamura, Shuichi Masuda, Takeshi Ogawa, Hirokazu Kobayashi, Kenichi Shirafuji, Reuben Toli Moli, Ikue Kozone, Kazuo Shin-ya, Shigenori Kumazawa. Solophenols B-D and solomonin: new prenylated polyphenols isolated from propolis collected from the Solomon Islands and their antibacterial activity. J. Agric. Food Chem. 2012, 60, 11765−11770.
  25. Teppei Kawahara, Takahiro Hosoya, Masao Tsukamoto, Sachiko Okabe, Hideki Yamamura, Masayuki Hayakawa, Hiroyuki Seimiya, Motoki Takagi, Kazuo Shin-ya. JBIR-120: a new growth inhibitor of hormone-refractory prostate cancer cells. J. Antibiot. 2012, 65, 373−375.
  26. Takahiro Hosoya, Fumie Yamasaki, Asami Nakata, Abdul Rahman, Idha Kusumawati, Noor Cholies Zaini, Hiroshi Morita. Inhibitors of nitric oxide production from Stemona javanica. Planta Med. 2011, 77, 256−258.
  27. Ahmad Kaleem Qureshi, Mat Ropi Mukhtar, Yusuke Hirasawa, Takahiro Hosoya, Alfarius E. Nugroho, Hiroshi Morita, Osamu Shirota, Khalit Mohamad, A. Hamid A. Hadi, Marc Litaudon, Khalijah Awang. Neolamarckines A and B, new indole alkaloids from Neolamarckia cadamba. Chem. Pharm. Bull. 2011, 59, 291−293.
  28. Alfarius E. Nugroho, Masatomo Sugai, Yusuke Hirasawa, Takahiro Hosoya, Khalijah Awang, A. Hamid A. Hadi, Wiwied Ekasari, Aty Widyawaruyanti, Hiroshi Morita. New antiplasmodial indole alkaloids from Hunteria zeylanica. Bioorg. Med. Chem. Lett. 2011, 21, 3417−3419.
  29. Ibrahim A. Najmuldeen, A. Hamid A. Hadi, Khalijah Awang, Khalit Mohamad, Kamal Aziz Ketuly, Mat Ropi Mukhtar, Soon-Lim Chong, Gomathi Chan, Mohd. Azlan Nafiah, Ng Seik Weng, Osamu Shirota, Takahiro Hosoya, Alfarius E. Nugroho, Hiroshi Morita. Chisomicines A-C, limonoids from Chisocheton ceramicus. J. Nat. Prod. 2011, 74, 1313−1317.
  30. Taku Shibue, Iwao Okamoto, Nobuyoshi Morita, Hiroshi Morita, Yusuke Hirasawa, Takahiro Hosoya, Osamu Tamura. Synthesis and biological evaluation of tubulysin D analogs related to stereoisomers of tubuvaline. Bioorg. Med. Chem. Lett. 2011, 21, 431−434.
  31. Takahiro Hosoya, Asami Nakata, Kazumasa Zaima, Jalifah Latip, Din Laily Bin, Noramly Muslim, Hiroshi Morita. Papuabalanols A and B, new tannins from Balanophora papuana. Chem. Pharm. Bull. 2010, 58, 738−741.
  32. Alfarius E. Nugroho, Yusuke Hirasawa, Takahiro Hosoya, Khalijah Awang, A. Hamid A. Hadi, Hiroshi Morita. Bisleucocurine A, a novel bisindole alkaloid from Leuconotis griffithii. Tetrahedron Lett. 2010, 51, 2589−2592.
  33. Hiroshi Morita, Yuta Nagakura, Takahiro Hosoya, Wisid Ekasari, Aty Widyawaruyanti, Kanami Mori-Yasumoro, Setsuko Sekita, Yusuke Hirasawa. Cephastigiamide A, and antiplasmodial activity of cephalotaxus alkaloids from Cephalotaxus harringtonia form a fastigiata. Heterocycles 2010, 81, 441−450.
  34. Jun Deguchi, Tomokazu Shoji, Alfarius E. Nugroho, Yusuke Hirasawa, Takahiro Hosoya, Osamu Shirota, Khalijah Awang, A. Hamid A. Hadi, Hiroshi Morita. Eucophylline, a tetracyclic vinylquinoline alkaloid from Leuconotis eugenifolius. J. Nat. Prod. 2010, 73, 1727−1729.
  35. Koichiro Koyama, Yusuke Hirasawa, Alfarius E. Nugroho, Takahiro Hosoya, Teh Chin Hoe, Kit-Lam Chan, Hiroshi Morita. Alsmaphorazines A and B, novel indole alkaloids from Alstonia pneumatophora. Org. Lett. 2010, 12, 4188−4191.
  36. Koichiro Koyama, Yusuke Hirasawa, Takahiro Hosoya, Teh Chin Hoe, Kit-Lam Chan, Hiroshi Morita. Alpneumines A-H, new anti-melanogenic indole alkaloids from Alstonia pneumatophora. Bioorg. Med. Chem. 2010, 18, 4415−4421.
  37. Yusuke Hirasawa, Tomokazu Shoji, Takashi Arai, Alfarius E. Nugroho, Jun Deguchi, Takahiro Hosoya, Nahoko Uchiyama, Yukihiro Goda, Khalijah Awang, A. Hamid A. Hadi, Motoo Shiro, Hiroshi Morita. Bisleuconothine A, an eburnane-aspidosperma bisindole alkaloid from Leuconotis griffithii. Bioorg. Med. Chem. Lett. 2010, 20, 2021−2024.
  38. Yuta Nagakura, Reiko Yamanaka, Yusuke Hirasawa, Takahiro Hosoya, Abdul Rahman, Idha Kusumawati, Noor Cholies Zaini, Hiroshi Morita. Gaudichaudysolin A, a new limonoid from the bark of Dysoxylum gaudichaudianum. Heterocycles 2010, 80, 1471−1477.
  39. Hiroshi Morita, Yuichiro Tomizawa, Jun Deguchi, Tokio Ishikawa, Hiroko Arai, Kazumasa Zaima, Takahiro Hosoya, Yusuke Hirasawa, Takayuki Matsumoto, Katsuo Kamata, Wiwied Ekasari, Aty Widyawaruyanti, Tutik Sri Wahyuni, Noor Cholies Zaini, Toshio Honda. Synthesis and structure-activity relationships of cassiarin A as potential antimalarials with vasorelaxant activity. Bioorg. Med. Chem. 2009, 17, 8234−8240.
  40. Intan Safinar Ismail, Yuta Nagakura, Yusuke Hirasawa, Takahiro Hosoya, Mohd. Izwan Mohd.Lazim, Nordin Hj Lajis, Motoo Shiro, Hiroshi Morita. Chrotacumines A-D, chromone alkaloids from Dysoxylum acutangulum. J. Nat. Prod. 2009, 72, 1879−1883.
  41. Intan Safinar Ismail, Yuta Nagakura, Yusuke Hirasawa, Takahiro Hosoya, Mohd Izwan Mohd Lazim, Nordin Hj Lajis, Hiroshi Morita. Acutaxylines A and B, two novel triterpenes from Dysoxylum acutangulum. Tetrahedron Lett. 2009, 50, 4830−4832.
  42. Kazumasa Zaima, Tomoko Hirata, Takahiro Hosoya, Yusuke Hirasawa, Koichiro Koyama, Abdul Rahman, Idha Kusumawati, Noor Cholies Zaini, Motoo Shiro, Hiroshi Morita. Biscarpamontamines A and B, an aspidosperma-iboga bisindole alkaloid and an aspidosperma-aspidosperma bisindole alkaloid, from Tabernaemontana sphaerocarpa. J. Nat. Prod. 2009, 72, 1686−1690.
  43. Shiori Oshimi, Aki Takasaki, Yusuke Hirasawa, Takahiro Hosoya, Khalijah Awang, A. Hamid A. Hadi, Wiwied Ekasari, Aty Widyawaruyanti, Hiroshi Morita. Delaumonones A and B, new antiplasmodial quassinoids from Laumoniera bruceadelpha. Chem. Pharm. Bull. 2009, 57, 867−869.
  44. Yosuke Matsuno, Jun Deguchi, Takahiro Hosoya, Yusuke Hirasawa, Chieko Hirobe, Motoo Shiro, Hiroshi Morita. Sucutiniranes C-F, cassane-type diterpenes from Bowdichia nitida. J. Nat. Prod. 2009, 72, 976−979.
  45. Yusuke Hirasawa, Saori Miyama, Takahiro Hosoya, Koichiro Koyama, Abdul Rahman, Idha Kusumawati, Noor Cholies Zaini, Hiroshi Morita. Alasmontamine A, A first tetrakis monoterpene indole alkaloid from Tabernaemontana elegans. Org. Lett. 2009, 11, 5718−5721.
  46. Takahiro Hosoya, Young Sook Yun, Akira Kunugi. Antioxidant phenylpropanoid glycosides from the leaves of Wasabia japonica. Phytochemistry 2008, 69, 827−832.
  47. Takahiro Hosoya, Midori A. Arai, Takashi Koyano, Thaworn Kowithayakorn, Masami Ishibashi. Naturally occurring small-molecule inhibitors of hedgehog/GLI-mediated transcription. ChemBioChem 2008, 9, 1082−1092.
  48. Midori A. Arai, Mina Sato, Keisuke Sawada, Takahiro Hosoya, Masami Ishibashi. Efficient synthesis of chromone and flavonoid derivatives with diverse heterocyclic units. Chemistry-An Asian J. 2008, 3, 2056−2064.
  49. Midori A. Arai, Chikashi Tateno, Takahiro Hosoya, Takashi Koyano, Thaworn Kowithayakorn, Masami Ishibashi. Hedgehog/GLI-mediated transcriptional inhibitors from Zizyphus cambodiana. Bioorg. Med. Chem. 2008, 16, 9420−9424.
  50. Takahiro Hosoya, Yui Kato, Yukinori Yamamoto, Masahiko Hayashi, K Kanki omiyama, Masami Ishibashi. Tryptophan 4-aminocinnamamides from a myxomycete Fuligo aurea. Heterocycles 2006, 69, 463−468.
  51. Takahiro Hosoya, Young Sook Yun, Akira Kunugi. Five novel flavonoids from Wasabia japonica. Tetrahedron 2005, 61, 7037−7044.
  52. Takahiro Hosoya, Yukinori Yamamoto, Yoshimasa Uehara, Masahiko Hayashi, Kanki Komiyama, Masami Ishibashi. New cytotoxic bisindole alkaloids with protein tyrosine kinase inhibitory activity from a myxomycete Lycogala epidendrum. Bioorg. Med. Chem. Lett. 2005, 15, 2776−2780.
著書
  1. 細谷孝博、熊澤茂則、津田孝範 他5名. 第26特集:食品と疾病−アントシアニン(担当:アントシアニンの構造と分布). Functional Food, 2014, 8, 68−73.
  2. 細谷孝博、熊澤茂則. NMRと多変量解析を用いた食品成分の総合評価〜世界の緑茶を例に〜1H-NMRスペクトルから分かること〜 化学と生物「今日の話題」. 2014, 52, 502−504.
  3. 細谷孝博. 天然由来のエイズ治療薬候補:ヴィピリニン. FARUMASHIA, 2012, 48, 330.
  4. 細谷孝博. 脚光を浴びる天然物:ルテオリンを例に. FARUMASHIA, 2006, 42, 741−742.