教員プロフィール

川嶋 芳枝

川嶋 芳枝

Kawashima Yoshie

健康薬学科/生体防御学研究室(准教授)

最終学歴

広島大学大学院 生物圏科学研究科 博士課程後期修了(生物機能科学専攻)

取得学位

博士(学術)(広島大学)

所属学会

日本発生生物学会 国際発生生物学会 日本分子生物学会 日本動物学会 日本薬学会

現在の専門分野

分子発生生物学、進化発生学、細胞生物学

現在の研究課題

脊椎動物における免疫組織・器官の進化発生学的解析

主要研究業績
  • カメ特異的形態形成におけるHox遺伝子および筋分化関連遺伝子の発現パターンと進化との関連
  • 耐熱性古細菌Thermoplasma volcaniumの全ゲノムDNA配列の決定
  • 古細菌、真核生物TBPの結晶構造と耐熱性の比較によるタンパク質熱の安定性機構の解析
  • 軟骨最終分化過程における副甲状腺ホルモンおよび副甲状腺ホルモン様ペプチド(PTH/PTHrP)の作用の解析
最近の研究業績
  1. Apoptosis occurs during early development of the bursa of Fabricius in chicken embryos. K. Makino, R. Omachi, H. Suzuki, K. Tomobe, T. Kawashima, T. Nakajima, and Y. Kawashima-Ohya, Biol. Pharm. Bull. in press
  2. Specificity of Fur Binding to the Oxidative Stress Response Gene Promoter in the Facultative Anaerobic Archaeon Thermoplasma volcanium. H. Minoshima, Y. Ikeda, M. Fujii, M. Satoh, Y. Ishikawa, Y. Kawashima-Ohya, K. Tomobe, Y. Itoh, Y. Omata and T. Kawashima. Biol. Pharm. Bull. 37(3):481-485 (2014)
  3. Age-related changes of forkhead transcription factor FOXO1 in the liver of senescence-accelerated mouse SAMP8, K. Tomobe, T. Shinozuka, T. Kawashima, Y. Kawashima-Ohya, and Y. Nomura. Archives of Gerontology and Geriatrics, 57, 417-422 (2013)
  4. Transcriptional factor Fur from Thermoplasma volcanium binds its own 4 promoter DNA in a divalent cation-dependent manner, Y. Ikeda, H. Minoshima, M. Satoh, T. Ishikawa, Y. Kawashima-Ohya, K. Tomobe, Y. Omata and T. Kawashima, J. Gen. Appl. Microbiol., 58, 465-473 (2012)
  5. Body plan of turtles: an anatomical, developmental and evolutionary perspective, H. Nagashima, S. Kuraku, K. Uchida, Y. Kawashima-Ohya, Y. Narita and S. Kuratani, Anat. Sci. Int., 87, 1-13 (2012)
  6. Hepatocyte growth factor is crucial for development of the carapace in turtles. Y. Kawashima-Ohya, Y. Narita, H. Nagashima, R. Usuda and S. Kuratani, Evol. Dev., 13, 260-268 (2011)
  7. Evolution of the turtle body plan by the folding and creation of new muscle connections H. Nagashima, F. Sugahara, M. Takechi., R. Ericsson., Y. Kawashima-Ohya., Y. Narita,Y., S. Kuratani, Science, 325,193-196(2009)
  8. On the carapacial ridge in turtle embryos: its developmental origin, function and the chelonian body plan. Hiroshi Nagashima, Shigehiro Kuraku, Katsuhisa Uchida, Yoshie Kawashima Ohya, Yuichi Narita and Shigeru Kuratani, Development 134, 2219-2226(2007)
  9. Unique features of Myf-5 in turtles: nucleotide deletion, alternative splicing, and unusual expression pattern, Yoshie Kawashima Ohya, Ryo Usuda, Shigehiro Kuraku and Shigeru Kuratani, Evolution & Development 8, 415-423(2006)
  10. Hox code in embryos of Chinese soft-shelled turtle Pelodiscus sinensis correlates with the evolutionary innovation in the turtle, Y. Kawashima Ohya, S. Kuraku and S. Kuratani, J. Exp. Zool (Mol. Dev. Evol.) 304(2), 107-18(2005),
  11. Origin of protein stability revealed by comparing crystal structure of TATA binding proteins. H. Koike, Y. Kawashima-Ohya, T. Yamasaki, L. Clowney, Y Katsuya, and M. Suzuki, Structure, 12, 157-168 (2004)
  12. Archaeal adaptation to higher temperatures revealed by genomic sequence of Thermoplasma volcanium. T. Kawashima, N. Amano, H. Koike, S. Makino, S. Higuchi, Y. Kawashima-Ohya, K. Watanabe, M. Yamazaki, K. Kanehori, T. Kawamoto, T. Nunoshiba, Y. Yamamoto, H. Aramaki, K. Makino, and M. Suzuki, Proc. Natl. Acad. Sci. USA.97(26), 14257-14262 (2000)
著書

H. Nagashima, S. Kuraku, K. Uchida, Y. Kawashima-Ohya, Y. Narita and S. Kuratani, Origin of the Turtle Body Plan: The Folding Theory to Illustrate Turtle-Specific Developmental Repatterning. D. B. Brinkman, P. A. Holroyd, and J. D. Gardner 編 “Morphology and Evolution of Turtles: Proceedings of the Gaffney Turtle Symposium in Honor of Eugene S. Gaffney (Vertebrate Paleobiology and Paleoanthropology)”, Springer-Verlag, Dordrecht.(2012)