教員プロフィール

橋本 敬太郎

橋本 敬太郎

Hashimoto Keitaro

臨床薬学科/臨床薬理学研究室 (教授)

最終学歴

東京大学 医学部

取得学位

医学博士 (東北大学)

所属学会

日本薬理学会、日本臨床薬理学会、日本心電学会

現在の専門分野

循環薬理学、抗不整脈薬、強心薬、疾患モデル、安全性薬理

現在の研究課題

QT延長薬の催不整脈作用
抗不整脈薬の開発

主要研究業績

疾患動物モデルを用いた抗不整脈薬の分類
新規抗不整脈薬の薬効、副作用解析
抗不整脈薬の心筋イオンチャネルに対する作用
強心薬の催不整脈作用
QT延長薬の催不整脈作用の評価方法の開発

最近の研究業績
  1. Hashimoto K.: Emerging antiarrhythmic agents: a personal view from the Far East, Expert Opinion on Emerging Drugs 16: 1-7, 2010
  2. Hashimoto K.: Torsades de pointes liability inter-model comparisons: The experience of the QT PRODACT initiative, Pharmacol Ther. 119: 195-198, 2008
  3. Amran MdS, Homma N, Hashimoto K.: Characterization of cardiac dysrhythmias induced by the modification of sodium channels and the inhibition of Na+-K+ ATPase in guine pigs, Saudi Pharmaceutical J. 16 (1): 50-57, 2008
  4. Ando K, Sugiyama A, Takahara A, Satoh Y, Ishizaka T, Nakamura Y, Hashimoto K.: Analysis of proarrhythmic potential of antipsychotics risperidone and olanzapine in anesthetized dogs、, Eur J Pharmacol, 558:151-8, 2007
  5. Takahara A, Nakamura H, Nouchi H, Tamura T, Tanaka T, Shimada H, Tamura M, Tsuruoka N, Takeda K, Tanaka H, Shigenobu K, Hashimoto K, Sugiyama A.: Analysis of arrhythmogenic profile in a canine model of chronic atrioventricular block by comparing in vitro effects of the class III antiarrhythmic drug nifekalant on the ventricular action potential indices between normal heart and atrioventricular block heart, J Pharmacol Sci. 103: 181-8, 2007
  6. Takahara A, Sugiyama A, Satoh Y, Iwasaki H, Nakamura Y, Hashimoto K : Cardiovascular profile of the canine torsades de pointes arrhythmia model assessed by echocardiographic and haemodynamic methods, Basic Clin Pharmacol Toxicol. 101: 35-40, 2007
  7. Hashimoto K.: Arrhythmia models for drug research: Classification of antiarrhythmic drugs, J. Pharmacol. Sci. 103: 333-346, 2007
  8. Chen J, Shen H, Nagasawa Y, Mitsui K, Tsurugi K, Hashimoto K.: Pravastatin inhibits arrhythmias induced by coronary artery ischemia in anesthetized rats, J. Pharmacol. Sci. 103: 317-322, 2007
  9. Takahara A, Nakamura H, Nouchi H, Tamura T, Tanaka T, Shimada H, Tamura M, Tsuruoka N, Takeda K, Tanaka H, Shigenobu K, Hashimoto K, Sugiyama A.: Analysis of arrhythmogenic profile in a canine model of chronic atrioventricular block by comparing in vitro effects of the class III antiarrhythmic drug nifekalant on the ventricular action potential indices between normal heart and atrioventroicular block heart, J. Pharmacol. Sci. 103: 181-188, 2007
  10. Takahara A, Sugiyama A, Satoh Y, Hashimoto K.: Comparison of four rate-correction algorisms for the ventricular repolarization period in assessing net effects of IKr blockers in dogs, J. Pharmacol. Sci. 102: 396-404, 2006
  11. Homma N, Amran MdS, Nagasawa Y, Hashimoto K.: Topics on the Na+/Ca2+ exchanger: Involvement of Na+/Ca2+ exchange system in cardiac triggered activity, J. Pharmacol. Sci. 102: 17-21, 2006
  12. Takahara A, Sugiyama A, Hashimoto K.: Characterization of the halothane-anesthetized guinea-pig heart as a model to detect the K+ channel blocker-induced QT-interval prolongation, Biol. Pharm. Bull. 29: 827-829, 2006
  13. Takahara A, Sugiyama A, Ishida Y, Satoh Y, Wang K, Nakamura Y, Hashimoto K: Long-term bradycardia caused by atrioventricular block can remodel the canine heart to detect the histamine H1 blocker terfenadine-induced torsades de pointes arrhythmias, Brit. J. Pharmacol. 147: 634-641, 2006
  14. Chiba K, Sugiyama A, Watanabe K, Takasuna K, Hashimoto K.: Acute hypokalemia may not be an effective way to sensitize the in situ canine heart for sparfloxacin-induced long QT syndrome, J. Pharmacol. Sci. 100: 88-92, 2006