教員プロフィール

石毛 敦

石毛 敦

Ishige Atsushi

漢方薬学科/漢方薬物学研究室(教授)

最終学歴

昭和薬科大学大学院

取得学位

医学博士

所属学会

日本東洋医学会、和漢医薬学会、日本薬理学会

現在の専門分野

漢方医学

現在の研究課題

漢方薬の遺伝子に与える影響

主要研究業績

漢方処方と方位(南山堂)石毛 敦、西村 甲 著

最近の研究業績
  1. A microarray analysis of gnotobiotic mice indicating that microbial exposure during the neonatal period plays an essential role in immune system development.
    Yamamoto M, Yamaguchi R, Munakata K, Takashima K, Nishiyama M, Hioki K, Ohnishi Y, Nagasaki M, Imoto S, Miyano S, Ishige A, Watanabe K.
    BMC Genomics 2012, 13:335
  2. Promotion of intestinal peristalsis by Bifidobacterium spp. capable of hydrolysing sennosides in mice.
    Matsumoto M, Ishige A, Yazawa Y, Kondo M, Muramatsu K, Watanabe K.
    PLoS One. 2012;7(2):e31700. Epub 2012 Feb 22.
  3. Administration of chinpi, a component of the herbal medicine ninjin-youei-to, reverses age-induced demyelination.
    Sato N, Seiwa C, Uruse M, Yamamoto M, Tanaka K, Kawakita T, Komatsu Y, Yasukawa A, Takao M, Kudo C, Hasegawa A, Ishige A, Watanabe K, Asou H.
    Evid Based Complement Alternat Med. 2011;2011:617438. Epub 2011 Jun 5.
  4. Maternal stress affects postnatal growth and the pituitary expression of prolactin in mouse offspring.

    Gao P, Ishige A, Murakami Y, Nakata H, Oka J, Munakata K, Yamamoto M, Nishimura K, Watanabe K.

    J Neurosci Res. 2011 Mar;89(3):329-40. doi: 10.1002/jnr.22550. Epub 2010 Dec 17.

    PMID:

    21259320

    [PubMed - in process]

    Related citations

      

  5. Stress on a postpartum mother inhibits the secretion of growth hormone in the offspring and causes persistent growth impairment.

    Nakata H, Watanabe K, Murakami Y, Gao P, Tsuiji K, Nishimura K, Plotnikoff GA, Kurihara N, Irie Y, Ishige A.

    Methods Find Exp Clin Pharmacol. 2009 Sep;31(7):433-41.

    PMID:

    19907718

    [PubMed - indexed for MEDLINE]

  6. Prolonged survival of fully mismatched cardiac allografts and generation of regulatory cells by Sairei-to, a Japanese herbal medicine. Zhang Q, Iwami D, Aramaki O, Yakubo S, Nishimura K, Ishige A, Watanabe K, Matsuno K, Shirasugi N, Niimi M. Transplantation. 2009 Jun 27;87(12):1787-91.
  7. Intestinal flora induces the expression of Cyp3a in the mouse liver. Toda T, Saito N, Ikarashi N, Ito K, Yamamoto M, Ishige A, Watanabe K, Sugiyama K. Xenobiotica. 2009 Apr;39(4):323-34.
  8. Orengedokuto and berberine improve indomethacin-induced small intestinal injury via adenosine. Watanabe-Fukuda Y, Yamamoto M, Miura N, Fukutake M, Ishige A, Yamaguchi R, Nagasaki M, Saito A, Imoto S, Miyano S, Takeda J, Watanabe K. J Gastroenterol. 2009;44(5):380-9. Epub 2009 Mar 25.
  9. A Kampo Medicine, Boi-ogi-to, Inhibits Obesity in Ovariectomized Rats. Yamakawa JI, Moriya J, Takahashi T, Ishige A, Motoo Y, Yoshizaki F, Kanda T. Evid Based Complement Alternat Med. 2007 Nov 14. [Epub ahead of print]
  10. A new monoclonal antibody, A3B10, specific for astrocyte-lineage cells recognizes calmodulin-regulated spectrin-associated protein 1 (Camsap1). Yamamoto M, Yoshimura K, Kitada M, Nakahara J, Seiwa C, Ueki T, Shimoda Y, Ishige A, Watanabe K, Asou H. J Neurosci Res. 2009 Feb;87(2):503-13.
  11. Identification of activated transcription factors from microarray gene expression data of Kampo medicine-treated mice. Yamaguchi R, Yamamoto M, Imoto S, Nagasaki M, Yoshida R, Tsuiji K, Ishige A, Asou H, Watanabe K, Miyano S. Genome Inform. 2007;18:119-29.
  12. Importance of the interferon-alpha system in murine large intestine indicated by microarray analysis of commensal bacteria-induced immunological changes. Munakata K, Yamamoto M, Anjiki N, Nishiyama M, Imamura S, Iizuka S, Takashima K, Ishige A, Hioki K, Ohnishi Y, Watanabe K. BMC Genomics. 2008 Apr 26;9:192.
  13. Administration of substance P during a primary immune response amplifies the secondary immune response via a long-lasting effect on CD8+ T lymphocytes. Ikeda Y, Takei H, Matsumoto C, Mase A, Yamamoto M, Takeda S, Ishige A, Watanabe K. Arch Dermatol Res. 2007 Sep;299(7):345-51. Epub 2007 Jul 21.
  14. Effect of herbal medicine Juzentaihoto on hepatic and intestinal heat shock gene expression requires intestinal microflora in mouse. Kato M, Ishige A, Anjiki N, Yamamoto M, Irie Y, Taniyama M, Kibe R, Oka J, Benno Y, Watanabe K. World J Gastroenterol. 2007 Apr 28;13(16):2289-97.
  15. Toki-to protects dopaminergic neurons in the substantia nigra from neurotoxicity of MPTP in mice. Sakai R, Irie Y, Murata T, Ishige A, Anjiki N, Watanabe K. Phytother Res. 2007 Sep;21(9):868-73.
  16. LKM512 yogurt consumption improves the intestinal environment and induces the T-helper type 1 cytokine in adult patients with intractable atopic dermatitis. Matsumoto M, Aranami A, Ishige A, Watanabe K, Benno Y. Clin Exp Allergy. 2007 Mar;37(3):358-70.
  17. An herbal medicine orengedokuto prevents indomethacin-induced enteropathy. Miura N, Fukutake M, Yamamoto M, Ohtake N, Iizuka S, Imamura S, Tsuchiya N, Ishimatsu M, Nakamura Y, Ishige A, Watanabe K, Kase Y, Takeda S. Biol Pharm Bull. 2007 Mar;30(3):495-501.
  18. Restoration of FcRgamma/Fyn signaling repairs central nervous system demyelination. Seiwa C, Yamamoto M, Tanaka K, Fukutake M, Ueki T, Takeda S, Sakai R, Ishige A, Watanabe K, Akita M, Yagi T, Tanaka K, Asou H. J Neurosci Res. 2007 Apr;85(5):954-66.
  19. Maintaining the redox-balance intact: gosha-jinki-gan but not insulin activates retinal soluble guanylate cyclase in diabetic rats. Cameron-Schaefer S, Kondo K, Ishige A, Tsuyama S, Uchida K, Hanawa T, Suematsu M, Watanabe K. Ophthalmic Res. 2006;38(2):95-104. Epub 2005 Dec 20.
  20. A Kampo formula Juzen-taiho-to induces expression of metallothioneins in mice. Anjiki N, Hoshino R, Ohnishi Y, Hioki K, Irie Y, Ishige A, Watanabe K. Phytother Res. 2005 Oct;19(10):915-7.
  21. Effects of Byakko-ka-ninjin-to on salivary secretion and bladder function in rats. Sakaguchi M, Goto K, Ichiki H, Hattori N, Iizuka A, Yamamoto M, Takeda S, Ishige A, Aburada M, Yasuda M, Yamamoto T. J Ethnopharmacol. 2005 Nov 14;102(2):164-9. Epub 2005 Aug 1.
  22. Anti-CD3 induces bi-phasic apoptosis in murine intestinal epithelial cells: possible involvement of the Fas/Fas ligand system in different T cell compartments. Miura N, Yamamoto M, Fukutake M, Ohtake N, Iizuka S, Ishige A, Sasaki H, Fukuda K, Yamamoto T, Hayakawa S. Int Immunol. 2005 May;17(5):513-22. Epub 2005 Mar 18.
  23. The herbal medicine Sho-saiko-to selectively inhibits CD8+ T-cell proliferation. Ohtake N, Yamamoto M, Takeda S, Aburada M, Ishige A, Watanabe K, Inoue M. Eur J Pharmacol. 2005 Jan 10;507(1-3):301-10. Epub 2005 Jan 6.Display Privacy Statement | Freedom of Information Act | Disclaimer
  24. Endogenous glucocorticoids are essential for maintaining prefrontal cortical cognitive function. Mizoguchi K, Ishige A, Takeda S, Aburada M, Tabira T. Endogenous glucocorticoids are essential for maintaining prefrontal cortical cognitive function. Mizoguchi K, Ishige A, Takeda S, Aburada M, Tabira T.
  25. Eugenol exhibits antidepressant-like activity in mice and induces expression of metallothionein-III in the hippocampus. Irie Y, Itokazu N, Anjiki N, Ishige A, Watanabe K, Keung WM. Brain Res. 2004 Jun 18;1011(2):243-6.
  26. Ninjin-yoei-to (Ren-Shen-Yang-Rong-Tang) and Polygalae radix improves scopolamine-induced impairment of passive avoidance response in mice. Egashira N, Yuzurihara M, Hattori N, Sakakibara I, Ishige A. Phytomedicine. 2003;10(6-7):467-73.
  27. Saiko-ka-ryukotsu-borei-to, a herbal medicine, ameliorates chronic stress-induced depressive state in rotarod performance. Mizoguchi K, Yuzurihara M, Ishige A, Aburada M, Tabira T. Pharmacol Biochem Behav. 2003 May;75(2):419-25.
  28. Chronic stress attenuates glucocorticoid negative feedback: involvement of the prefrontal cortex and hippocampus. Mizoguchi K, Ishige A, Aburada M, Tabira T. Neuroscience. 2003;119(3):887-97.
  29. Effect of Dai-kenchu-to (Da-Jian-Zhong-Tang) on the delayed intestinal propulsion induced by chlorpromazine in mice. Satoh K, Kase Y, Yuzurihara M, Mizoguchi K, Kurauchi K, Ishige A. J Ethnopharmacol. 2003 May;86(1):37-44. PMID: 12686439 [PubMed - indexed for MEDLINE] Related Articles
  30. Effects of the Japanese herbal medicine Keishi-bukuryo-gan and 17beta-estradiol on calcitonin gene-related peptide-induced elevation of skin temperature in ovariectomized rats. Noguchi M, Ikarashi Y, Yuzurihara M, Kase Y, Chen JT, Takeda S, Aburada M, Ishige A. J Endocrinol. 2003 Mar;176(3):359-66.
  31. Possible involvement of suppression of Th2 differentiation in the anti-allergic effect of Sho-seiryu-to in mice. Ikeda Y, Kaneko A, Yamamoto M, Ishige A, Sasaki H. Jpn J Pharmacol. 2002 Dec;90(4):328-36.
  32. Pharmacological characteristics of Ryokan-kyomi-shinge-nin-to, an antiallergic Kampo medicine. Sakaguchi M, Ikeda Y, Kido T, Yuzurihara M, Kase Y, Yamamoto M, Ishige A, Sasaki H. Biol Pharm Bull. 2002 Dec;25(12):1562-5.
  33. Components of Panax ginseng that improve accelerated small intestinal transit. Hashimoto K, Satoh K, Murata P, Makino B, Sakakibara I, Kase Y, Ishige A, Higuchi M, Sasaki H. J Ethnopharmacol. 2003 Jan;84(1):115-9.
  34. Saiko-ka-ryukotsu-borei-to, an herbal medicine, prevents chronic stress-induced disruption of glucocorticoid negative feedback in rats. Mizoguchi K, Yuzurihara M, Ishige A, Sasaki H, Tabira T. Life Sci. 2002 Nov 22;72(1):67-77.
  35. Component of Zingiber officinale that improves the enhancement of small intestinal transport. Hashimoto K, Satoh K, Murata P, Makino B, Sakakibara I, Kase Y, Ishige A, Higuchi M, Sasaki H. Planta Med. 2002 Oct;68(10):936-9.
  36. Up-regulation of calcitonin gene-related peptide receptors underlying elevation of skin temperature in ovariectomized rats. Noguchi M, Ikarashi Y, Yuzurihara M, Mizoguchi K, Kurauchi K, Chen JT, Ishige A. J Endocrinol. 2002 Oct;175(1):177-83.
  37. Dopamine-receptor stimulation in the prefrontal cortex ameliorates stress-induced rotarod impairment. Mizoguchi K, Yuzurihara M, Nagata M, Ishige A, Sasaki H, Tabira T. Pharmacol Biochem Behav. 2002 Jun;72(3):723-8.
  38. The herbal medicine Dai-kenchu-to and one of its active components [6]-shogaol increase intestinal blood flow in rats. Murata P, Kase Y, Ishige A, Sasaki H, Kurosawa S, Nakamura T. Life Sci. 2002 Mar 15;70(17):2061-70.
  39. Chronic stress impairs rotarod performance in rats: implications for depressive state. Mizoguchi K, Yuzurihara M, Ishige A, Sasaki H, Tabira T. Pharmacol Biochem Behav. 2002 Jan-Feb;71(1-2):79-84.
  40. The herbal medicine Shosaiko-to exerts different modulating effects on lung local immune responses among mouse strains. Ohtake N, Nakai Y, Yamamoto M, Ishige A, Sasaki H, Fukuda K, Hayashi S, Hayakawa S. Int Immunopharmacol. 2002 Feb;2(2-3):357-66.
  41. Effects of San'o-shashin-to and the constituent herbal medicines on theophylline-induced increase in arterial blood pressure of rats. Sanae F, Komatsu Y, Chisaki K, Kido T, Ishige A, Hayashi H. Biol Pharm Bull. 2001 Oct;24(10):1137-41.
  42. Dai-kenchu-to enhances accelerated small intestinal movement. Satoh K, Kase Y, Hayakawa T, Murata P, Ishige A, Sasaki H. Biol Pharm Bull. 2001 Oct;24(10):1122-6.
  43. An inhibitory effect of cytokine-induced neutrophil chemoattractant on corticotropin-releasing factor-induced increase in locomotor activity. Terawaki K, Koike K, Yuzurihara M, Kurauchi K, Ishige A, Sasaki H, Murakami K, Inoue M. Brain Res. 2001 Oct 26;917(1):133-7.