教員プロフィール

出雲 信夫

出雲 信夫

Izumo Nobuo

健康薬学科/食化学研究室 (准教授)

最終学歴

摂南大学薬学部博士後期課程

取得学位

博士(薬学)

所属学会

日本薬理学会(評議員)、日本神経精神薬理学会(評議員)、日本薬学会、日本脳科学会、日本骨代謝学会、応用薬理研究会、日本医療薬学会、日本ラクトフェリン学会、パクチーアカデミー協会(理事)

現在の専門分野

薬理学

現在の研究課題

うつ病の発症メカニズムの解明と骨粗鬆症治療薬の検討

主要研究業績
  • ステロイドホルモンや遺伝子の異常状態における行動の変化と抗うつ薬の効果の研究
    Glob Drugs Therap, Volume 2(5): 1-5(2017) . Journal of Brain Science 46 5-19(2016) . Neurochemistry International.69:9-13(2014) . Behavioural Brain Research 227(1)1-6(2012) . Molecular Autism 3(11)1-9(2012)
  • 骨粗鬆症治療薬や機能性物質の骨代謝への効果の研究
    Biol Pharm Bull 40, 1934-1940(2017) . J Pharmacol Sci 135 22-28(2017) . European Journal of Pharmacology 762 150-157(2015) . Lactoferrin 2015 114-119(2015) . International Journal of Sport and Health Science (4) 10-18(2006) . Methods Find Exp Clin Pharmacol 23(7) 389-394(2001) . Biochem Biophys Res Commun 280(1) 348-352(2001) . Jpn J Pharmacol 82(3) 240-246(2000)
  • 新規ナノステロイド製剤についての研究
    Nippon Rinsho. Review. Japanese. 64(2) 329-334. (2006) . J Control Release 20(105)1-2 68-76(2005) . Ann Rheum Dis 64(8) 1132-1136(2005)
最近の研究業績
  1. Effects of Multiple Comparisons on Integration of Stratified Analysis: On the Serum TG Decreasing Effect of EPA / DHA in Healthy Subjects Kohsuke Hayamizu, Nobuo Izumo, Makoto Nakano, Maki Matsuyama, Shigetoshi Tsuzuki, Yasuo Watanabe . Pharmacometrics 93 83-89(2017)
  2. Effects of the Oral Intake of Kaempferia parviflora Extract on Whole Body Fat and Skeletal Muscle Percentages in Japanese Women: Randomized Double-Blind Placebo-Controlled Parallel Group Comparison Study Shigetoshi Tsuzuki, Makoto Nakano, Nobuo Izumo, Kohsuke Hayamizu, Maki Matsuyama, Yasuo Watanabe . Pharmacometrics 93 55-62(2017)
  3. Effect of Lactoferrin on decrease of early activity in rats Nobuo Izumo, Yukiko Ishibashi, Yukie Ono, Shinzi Kagaya, Megumi Furukawa, Kohsuke Hayamizu, Makoto Nakano, Tatsuo Hoshino, Shigetoshi Tsuzuki, and Yasuo Watanabe . LACTOFERRIN 2017, 97-100
  4. Effect of Lactoferrin on increase in melanin of the skin by UVA radiation Nobuo Izumo, Haruka Komatsuzaki, Shinzi Kagaya, Maki Yamazoe, Masahiro Toho, Kohsuke Hayamizu, Makoto Nakano, Tatsuo Hoshino, Shigetoshi Tsuzuki, and Yasuo Watanabe . LACTOFERRIN 2017, 111-114
  5. Effects of the Antiepileptic Drugs Phenytoin, Gabapentin, and Levetiracetam on Bone Strength, Bone Mass, and Bone Turnover in Rats Junkichi Kanda, Nobuo Izumo, Yoshiko Kobayashi, Kenji Onodera, Taketoshi Shimakura, Noriaki Yamamoto, Hideaki E Takahashi, and Hiroyuki Wakabayashi . Biol Pharm Bull 40, 1934-1940(2017)
  6. Treatment with Antiepileptic Agent Perampanel Suppresses Bone Formation and Enhances Bone Resorption: A Bone Histomorphometric Study in Mice Junkichi Kanda, Nobuo Izumo, Yoshiko Kobayashi, Kenji Onodera, Taketoshi Shimakura, Noriaki Yamamoto, Hideaki E Takahashi and Hiroyuki Wakabayashi . J Hard Tissue biol 26(4) 405-410(2017)
  7. Effects of the antiepileptic drugs topiramate and lamotrigine on bone metabolism in rats Junkichi KANDA, Nobuo Izumo, Yoshiko KOBAYASHI, Kenji ONODERA, Taketoshi SHIMAKURA, Noriaki YAMAMOTO, Hideaki E TAKAHASHI, and Hiroyuki WAKABAYASHI . Biomed Res (Tokyo) 38(5) 297-305 (2017)
  8. Effect of the antidiabetic agent pioglitazone on bone metabolism in rats Junkichi Kanda, Nobuo Izumo, Yoshiko Kobayashi, Kenji Onodera, Taketoshi Shimakura, Noriaki Yamamoto, Hideaki E Takahashi, Hiroyuki Wakabayashi . J Pharmacol Sci 135 22-28(2017)
  9. MU314, a novel selective estrogen receptor modulator (SERM), improves estrogen-dependent depressive behaviors Izumo N, Ishibashi Y, Ono Y, Toho M, Sumino A, Kameyama T, Morikawa T, Shiba Y, Watanabe Y and Manabe T . Glob Drugs Therap, Volume 2(5): 1-5(2017)
  10. Chronic irradiation with low-dose-rate 137Cs-γ rays inhibits NGF-induced neurite extension of PC12 cells via Ca2+/calmodulin-dependent kinase II activation Katoh Shinsuke, Kobayashi Junya, Umeda Tomonobu, Kobayashi Yoshiko, Nobuo Izumo and Suzuki Takahiko . J Radi Res, pp. 1–7 doi: 10.1093/jrr/rrx032(2017)
  11. Potentiation of nerve growth factor-induced neurite outgrowth by a novel SERM, MU314, PC12 cells Nobuo Izumo, Yukie Ono, Chinatsu Inatomi, Masahiro Toho, Shinsuke Katoh, Shigetoshi Tsuzuki, Takayuki Manabe, Yasuo Watanabe . Pharmacometrics 92 45-52(2017)
  12. Fluvoxamine reverses estrogen-dependent decline in voluntary activitise and decreased and amygdala levels of serotonin in ovareectomized rats. Yukiko Ishibashi, Nobuo Izumo, Keiko Iwata, Tomomi Morikawa, Kameyama Toshiki, Yasuo Watanabe, Takayuki Manabe and Hideo Matsuzaki . Journal of Brain Science 46 5-19(2016)
  13. X ray Irradiation Promotes Nerve Growth Factor-induced Neurite Extension in PC12 cells. Shinsuke Katoh, Junya Kobayashi, Tomonobu Umeda, Yoshiko Kobayashi, Nobuo Izumo, and Takahiko Suzuki B . RADIOISOTOPES, 65, 137-143(2016)
  14. Application of Mohs’ Paste to Treat Hemorrhages Induced by Disintegrated Breast Cancer Tumors and Evaluation of this Hemostatic Mechanism Using an Animal Model. Nobuo Izumo, Masato Shigeyama, Maho Taguchi, Daichi Nagashima, Syota Nagano, Eri Kikuchi, Koji Hashiguchi, Jun Fujisawa. Mikio Murata, Takashi Isobe, Yasuhiro Kajiwara, Kazuto Isuzugawa, Nobumitsu Hanioka, Yasuo Watanabe and Hitomi Teramachi . Japanese Journal of Pharmaceutical Health Care and Sciences, 42(4), 246-254(2016)
  15.  Modulation of osteoblast differentiation and bone mass by 5-HT2A receptor signaling in mice. Kenjiro Tanaka, Takao Hirai, Yukiko Ishibashi, Nobuo Izumo, Akifumi Togari . European Journal of Pharmacology 762 150-157(2015)
  16. Therapeutic effect of lactoferrin on decreased bone mass by OVX mice. Nobuo Izumo, Seiji Niimoto, Yukiko Ishibashi, Maki Tsuji, Yasuo Watanabe, Shinji Kagaya, Tatsuo Hoshino . Lactoferrin 2015 114-119(2015)
  17. Integrated Analysis on Effect of Eicosapentaenoic Acid (EPA) and Docosahexaenoic Acid (DHA) on Fasting Serum Triglyceride Level in Borderline Subjects of Hyperlipidemia. Kohsuke Hayamizu, Nobuo Izumo, Maki Tsuji and Tomoko Tsuji . Pharmacometrics 88 97-103(2015)
  18. Comparative Effects of between Stevia Fermented by Lactic Acid Bacteria (SW03) and Sugar on the Reduction of Errors of Calculations Induced by Fatigue in Human Study. Maki Tsuji, Nobuo Izumo, Hiroyuki Kuwahara, Shigetoshi Tsuzuki, Yasuo Watanabe . Pharmacometrics 88 81-86(2015)
  19. Fluvoxamine moderates reduced voluntary activity following chronic dexamethasone infusion in mice via recovery of BDNF signal cascades. Terada K, Izumo N, Suzuki B, Karube Y, Morikawa T, Ishibashi Y, Kameyama T, Chiba K, Sasaki N, Iwata K, Matsuzaki H, Manabe T. . Neurochemistry International.69:9-13(2014)
  20. Addition of α-Glucosidase Inhibitors to the Dipeptidyl Peptidase-4 Inhibitor Alogliptin Has Rapid Synergistic Effects on Blood Incretin Levels. Jumpei Shikuma, Takaaki Kobayashi, Nobuo Izumo, Kenshi Kan, Atushi Kumakura, Rokuro Ito, Takashi Miwa, Akira Kanazawa, Masato Odawara. . Pharmacometrics 86 57-61(2014)
  21. Prediction of inter-individual variability in pharmacokinetics of CYP2C19 substrates in humans. Chiba K, Shimizu K, Kato M, Nishibayashi T, Terada K, Izumo N, Sugiyama Y. . Drug Metabolism and Pharmacokinetics. 29(5) 379-86(2014)
  22. Inhibition of nerve growth factor-induced neurite outgrowth from PC12 cells by dexamethasone: signaling pathways through the glucocorticoid receptor and phosphorylated Akt and ERK1/2. Terada K, Kojima Y, Watanabe T, Izumo N, Chiba K, Karube Y. . PLoS One. 9(3) e93223(2014)
著書
  1. 薬の効くプロセス(ネオメディカル)2017年
  2. コンパス薬理学(南江堂)2017年
  3. 薬理学実習書(横浜薬科大学)2015年~
  4. わかりやすい薬の効くプロセス 改訂版(ネオメディカル)2013年
  5. 薬剤師国家試験 -新国家試験形式 解答・解説集(横浜薬科大学)2011年~
  6. Clinical Pharmaceutical English I(横浜薬科大学)2011年~
  7. ファーマシューティカルノート 疾病と薬物治療学(医学評論社)2008年